The Latvian Biomedical Research and Study Centre (BMC) is the leading scientific
institute in molecular biology and biomedicine in Latvia. BMC serves as the main processor of Genome Database of Latvian Population (LGDB), providing infrastructure, personnel resources and scientific experience.
LGDB is a national biobank that gathers, maintains and process health information data and genetic material collection of Latvian population, that serves for research, prophylaxis and therapeutic purposes. Since 2016 BMC have been admitted as a National Nod of BBMRI-ERIC, therefore, current LGDB activities include the establishment of a national biobank network.
Currently, LGDB comprises biosamples and associated phenotypic and clinical information of over 30’356 that constitutes 1,5 % of Latvian population. Biosamples stored in LGDB comprise DNA, plasma, serum and white blood cells. Genetic testing and specific biochemical analysis are performed and stored in LGDB for specific project based sample groups. Initially, LGDB was designed to be compatible with the BBMRI framework. Participant recruitment is based on three enrolment segments – disease-oriented, population-based and healthy volunteers.
The collected samples have been used for research in national and international science projects (included in consortia, GWASs, replications), LGDB has served as a resource for design and validation of several clinically important genetic tests, thus directly interacting with health care system of the Republic of Latvia. Development directions of LGDB include further active participation in BBMRI-ERIC initiatives, enrichment, and harmonization of collected biosamples and data, follow-up of selected participant groups, continued networking, and participation in collaboration projects aiming to remain open access research platform.