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EUCAN-Connect

EUCAN-Connect: A federated FAIR platform enabling large-scale analysis of high-value cohort data connecting Europe and Canada in personalized health

Topic:  SC1-BHC-05-2018, International flagship collaboration with Canada for human data storage, integration and sharing to enable personalised medicine approaches

Type of Action: RIA

Duration: 60 months

Start date: 1 Jan 2019

Grant agreement: 824989

Web: not yet available

Total request Grant by Consortium: €5,999,703.75

Total request Grant by BBMRI-ERIC: €399,326.25

Linked Third Parties/BBMRI-ERIC Framework Agreement: none

Benefit/tasks for BBMRI-ERIC: EUCAN-Connect platform and collaborations will be coordinated through BBMRI-ERIC and Maelstrom Research (Canada) to sustain long-term benefits to science and citizens worldwide.

 

Abstract

Rapid progress in information and biotechnologies offers the promise of better, personalized health strategies using rich phenotypic, environmental and molecular (omics) profiles of every individual. To capitalize on this great promise, key challenge is to relate these profiles to health and disease while accounting for high diversity in individuals, populations and environments. Both Europe and Canada have long-term investments in population-based prospective cohort studies providing essential longitudinal data. These data must be analysed in unison to reach statistical power,
however, presently cohort data repositories are scattered, hard to search and integrate, and data protection and governance rules discourage central pooling.

EUCAN-Connect will enable large-scale integrated cohort data analysis for personalized and preventive healthcare across EU and Canada. This will be based on an open, scalable data platform for cohorts, researchers and networks, incorporating FAIR principles (Findable, Accessible, Interoperable, Reusable) for optimal reuse of existing data, and building on maturing federated technologies, with sensitive data kept locally and only results being shared and integrated, in line with key ELSI and governance guidelines. Widespread uptake will be promoted via beyond state-of-the-art research in close collaboration with leading cohort networks, focused on early-life origins of cardio-metabolic, developmental, musculoskeletal and respiratory health and disease impacting human life course.

To address challenges of sustainability and curation, we will deliver innovative solutions for distributed, low-cost data harvesting and preservation, community curation/harmonization, privacy protection, open source bioinformatics toolbox development, and international governance. EUCAN-Connect platform and collaborations will be coordinated through BBMRI-ERIC (EU) and Maelstrom Research (Canada) to sustain long-term benefits to science and citizens worldwide.

 

EUCAN-Connect is funded by the European Union’s Horizon 2020 research and innovation programme under grant agreement No 824989.

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The website was co-funded within ADOPT BBMRI-ERIC, a project that has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 676550.
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